Kugoh T, Hosokawa K
Folia Psychiatr Neurol Jpn. 1983;37(3):277-81. doi: 10.1111/j.1440-1819.1983.tb00330.x.
The frequency of the cases which showed the toxic levels and the relationship between the serum levels and mental symptoms were discussed on the basis of determination of the serum antiepileptic drugs. This was aimed at recognizing the effects of drug therapy in the appearance of some psychiatric symptoms in patients with epilepsy. The serum levels of folate and vitamin B12 were measured simultaneously to examine the relationship with some mental change. The direct cause-and-effect relationship could not be demonstrated between the serum levels and the mental symptoms.
基于血清抗癫痫药物的测定，讨论了显示中毒水平的病例频率以及血清水平与精神症状之间的关系。目的是认识药物治疗对癫痫患者某些精神症状出现的影响。同时测量血清叶酸和维生素B12水平，以研究其与某些精神变化的关系。血清水平与精神症状之间无法证明存在直接的因果关系。
