抗惊厥药、叶酸与癫痫患者的记忆功能障碍
Anticonvulsants, folic acid and memory dysfunction in epileptics.
作者信息
Butlin A T, Danta G, Cook M L
出版信息
Clin Exp Neurol. 1984;20:57-62.
PMID:6439448
Abstract
The results of a survey of 116 epileptic patients treated by monotherapy with phenytoin, carbamazepine and sodium valproate are described. No significant correlations were found between memory performance and serum anticonvulsant levels. However, correlations were found between memory performance and levels of red cell folate. The hypothesis that phenytoin may impair memory performance through the reduction of folate is discussed.
摘要
本文描述了对116例接受苯妥英钠、卡马西平和丙戊酸钠单一疗法治疗的癫痫患者的调查结果。未发现记忆表现与血清抗惊厥药水平之间存在显著相关性。然而，发现记忆表现与红细胞叶酸水平之间存在相关性。文中讨论了苯妥英钠可能通过降低叶酸水平损害记忆表现的假说。
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