Karpe B, Plöen L, Ritzén E M
Int J Androl. 1984 Apr;7(2):154-66. doi: 10.1111/j.1365-2605.1984.tb00771.x.
Rats were made bilaterally cryptorchid at 17 days of age and bilateral orchidopexy performed at 34 days of age. The epididymal content of androgen binding protein (ABP), the weight and morphology of the testis, the cross-sectional area of seminiferous tubules and the testicular concentration of testosterone were then studied at 34, 42, 59 and 120 days of age. Cryptorchidism was followed rapidly by progressive inhibition of spermatogenesis and testicular growth as well as by decreased Sertoli cell secretion of ABP. Orchidopexy resulted in a gradual restoration of spermatogenesis, and all impaired parameters seemed to improve at the same, fairly slow rate. Restoration was not complete, but by 120 days of age the morphological appearance of the testis was compatible with recovery of normal fertility.
大鼠在17日龄时进行双侧隐睾手术，并在34日龄时进行双侧睾丸固定术。然后在34、42、59和120日龄时研究附睾中雄激素结合蛋白（ABP）的含量、睾丸的重量和形态、生精小管的横截面积以及睾丸中睾酮的浓度。隐睾症迅速导致生精和睾丸生长的进行性抑制，以及支持细胞ABP分泌减少。睾丸固定术导致生精功能逐渐恢复，所有受损参数似乎以相同的、相当缓慢的速度改善。恢复并不完全，但到120日龄时，睾丸的形态外观与正常生育能力的恢复相符。
