四环素与金属离子的络合作用与光敏化的关系。
Complexation of tetracyclines with metal ions in relation to photosensitization.
作者信息
Riaz M, Pilpel N
出版信息
J Pharm Pharmacol. 1984 Mar;36(3):153-6. doi: 10.1111/j.2042-7158.1984.tb06929.x.
Abstract
It has been shown by spectroscopy and by a Photosensitive Index method, involving measurements of interfacial tension, that Cu2+ and Ni2+ form 2:1 complexes with oxytetracycline and 1:1 complexes with demethylchlortetracycline. Fe2+, Zn2+, Mg2+ and Ca2+ form weaker 1:1 complexes with both drugs. The possibility is discussed of using metal ions to reduce photosensitization by tetracyclines in-vivo.
摘要
光谱学和一种涉及界面张力测量的光敏指数方法已表明，Cu2+和Ni2+与土霉素形成2:1络合物，与去甲金霉素形成1:1络合物。Fe2+、Zn2+、Mg2+和Ca2+与这两种药物形成较弱的1:1络合物。文中讨论了利用金属离子降低四环素在体内光敏作用的可能性。
Zotero 插件