Loiacono R E, Story D F
J Pharm Pharmacol. 1984 Apr;36(4):262-4. doi: 10.1111/j.2042-7158.1984.tb04364.x.
Acetylcholine (0.01-10 mumol litre-1) relaxed normal rings (endothelium-retained) of rabbit pulmonary artery precontracted with clonidine (10 mumol litre-1) while preparations with the endothelium removed responded with contraction only. Removal of the endothelium had no effect on contractions of the preparation to clonidine or field stimulation of the adventitial nerves (2 Hz, 10 s). Furthermore, the inhibitory effect of acetylcholine (0.3 and 1.0 mumol litre-1) on contractions induced by field stimulation was not influenced by the vascular endothelium.
乙酰胆碱（0.01 - 10微摩尔/升）可使预先用可乐定（10微摩尔/升）预收缩的兔肺动脉正常环（保留内皮）舒张，而去除内皮的标本仅出现收缩反应。去除内皮对标本对可乐定的收缩反应或外膜神经的场刺激（2赫兹，10秒）没有影响。此外，乙酰胆碱（0.3和1.0微摩尔/升）对场刺激诱导的收缩的抑制作用不受血管内皮的影响。
