Sankey M G, Gulaid A, Kaye C M
J Pharm Pharmacol. 1984 Apr;36(4):276-7. doi: 10.1111/j.2042-7158.1984.tb04370.x.
A new stereospecific hplc method that is capable of simultaneously quantitating the S-(-)- and R-(+)-enantiomers of acebutolol and its major metabolite, diacetolol, in plasma and urine, is described. When applied to the assay of biological fluids collected during single and chronic oral dosing with acebutolol (Sectral), this procedure failed to reveal any important stereoselectivity in the disposition of either acebutolol or diacetolol in man. This may occur because acebutolol is metabolized by hydrolysis and N-acetylation, whereas the other beta-blockers which exhibit some degree of stereoselective disposition (e.g. metoprolol and propranolol) are primarily metabolized by oxidation.
本文描述了一种新的立体专一性高效液相色谱法，该方法能够同时定量测定血浆和尿液中醋丁洛尔及其主要代谢物双醋洛尔的S-(-)-和R-(+)-对映体。当应用于单次和长期口服醋丁洛尔（心得静）期间收集的生物体液的测定时，该程序未能揭示人体中醋丁洛尔或双醋洛尔处置过程中的任何重要立体选择性。这可能是因为醋丁洛尔通过水解和N-乙酰化代谢，而其他表现出一定程度立体选择性处置的β受体阻滞剂（如美托洛尔和普萘洛尔）主要通过氧化代谢。
