Grindulis K A, Calverley M, Cox C
J Rheumatol. 1984 Apr;11(2):211-2.
Seven clinical and laboratory indices of disease activity were compared with serum vitamin B12 levels in 32 patients with rheumatoid arthritis treated with penicillamine (16 patients) or sulphasalazine (16 patients) for up to 24 weeks. Prior to treatment each patient had active disease but a normal or low serum vitamin B12 concentration. During treatment, significant improvements occurred in all clinical and laboratory measurements but vitamin B12 levels were unchanged. We have been unable to confirm a reported positive association between rheumatoid disease activity and serum B12 concentration.
在32例接受青霉胺（16例）或柳氮磺胺吡啶（16例）治疗长达24周的类风湿性关节炎患者中，将7项疾病活动的临床和实验室指标与血清维生素B12水平进行了比较。治疗前，每位患者均患有活动性疾病，但血清维生素B12浓度正常或偏低。治疗期间，所有临床和实验室测量指标均有显著改善，但维生素B12水平未发生变化。我们无法证实所报道的类风湿疾病活动与血清B12浓度之间的正相关关系。
