Fonseca V, Mohiuddin J, Weerakoon J, Boss M, Mikhailidis D P, Dandona P
Lancet. 1984 May 19;1(8386):1093-5. doi: 10.1016/s0140-6736(84)92507-8.
To confirm recent observations that some vitamin D deficient osteomalacic patients had low plasma creatinine concentrations, low urinary creatinine excretion, and a paradoxically low creatinine clearance, and whether these changes were due to vitamin D deficiency per se, these measurements were made in patients before and after vitamin D supplementation. The pretreatment levels were also compared with those in healthy controls and in non-osteomalacic patients without renal disease. The above changes were confirmed. After treatment with vitamin D, plasma creatinine concentrations rose, but urinary creatinine excretion and creatinine clearance did not alter. These data indicate the limitation of creatinine clearance as an index of renal function in vegetarian osteomalacic patients. Furthermore, they demonstrate the effect of vitamin D deficiency and its reversal on plasma creatinine concentrations.
为了证实近期的观察结果，即一些维生素D缺乏性骨软化症患者血浆肌酐浓度低、尿肌酐排泄量低且肌酐清除率反常地低，以及这些变化是否归因于维生素D本身缺乏，我们对患者在补充维生素D之前和之后进行了这些测量。还将治疗前的水平与健康对照组以及无肾脏疾病的非骨软化症患者的水平进行了比较。上述变化得到了证实。用维生素D治疗后，血浆肌酐浓度升高，但尿肌酐排泄量和肌酐清除率没有改变。这些数据表明肌酐清除率作为素食性骨软化症患者肾功能指标的局限性。此外，它们证明了维生素D缺乏及其纠正对血浆肌酐浓度的影响。
