Boag F, Weerakoon J, Ginsburg J, Havard C W, Dandona P
J Clin Pathol. 1985 Jan;38(1):60-3. doi: 10.1136/jcp.38.1.60.
To assess whether patients with anorexia nervosa have abnormalities in creatinine clearance, we measured plasma creatinine concentration, urinary creatinine excretion, and creatinine clearance in 10 patients with anorexia nervosa before and during treatment. Urinary creatinine excretion and creatinine clearance were diminished in all patients. Nine patients had significant decreases in their plasma creatinine and creatinine clearance was increased even when corrected for body weight and body surface area respectively. The patient who did not show these changes in plasma creatinine concentration and creatinine clearance had gained only 4% in body weight. Body weight and corrected creatinine clearance were significantly correlated, as were percentage increases in body weight and creatinine clearance. Thus anorexia nervosa is associated with a reversible decrease in creatinine clearance. Increase in body weight appears to be cardinal to the recovery of renal function in these patients.
为评估神经性厌食症患者的肌酐清除率是否存在异常，我们在10例神经性厌食症患者治疗前及治疗期间测量了血浆肌酐浓度、尿肌酐排泄量及肌酐清除率。所有患者的尿肌酐排泄量和肌酐清除率均降低。9例患者的血浆肌酐显著下降，且肌酐清除率在分别校正体重和体表面积后仍升高。血浆肌酐浓度和肌酐清除率未出现这些变化的患者体重仅增加了4%。体重与校正后的肌酐清除率显著相关，体重增加百分比与肌酐清除率也显著相关。因此，神经性厌食症与肌酐清除率的可逆性降低有关。体重增加似乎是这些患者肾功能恢复的关键。
