Steranka L R
Naunyn Schmiedebergs Arch Pharmacol. 1984 Mar;325(3):198-204. doi: 10.1007/BF00495943.
The decrease in striatal dopamine (DA) at 1 week after the administration of a single injection of (+)-amphetamine sulfate (9.2 mg/kg) to iprindole-treated (10 mg/kg of iprindole hydrochloride) rats was prevented by haloperidol (0.2 mg/kg), sulpiride (32 mg/kg), pimozide (2 mg/kg), chlorpromazine hydrochloride (3.5 mg/kg), fluphenazine 2-hydrochloride (0.25 mg/kg) and (+)-butaclamol hydrochloride (1 mg/kg) but not by (-)-butaclamol hydrochloride (1 mg/kg) or clozapine (40 mg/kg). The same dose of sulpiride did not significantly attenuate the rotational behavior induced by the administration of (+)-amphetamine sulfate (9.2 mg/kg) to iprindole-treated rats with unilateral aspiration lesions of the striatum. The concentration of amphetamine in the brains of iprindole-treated rats at 8 h after (+)-amphetamine sulfate (9.2 mg/kg) administration was not altered by the coadministration of haloperidol (1 mg/kg), sulpiride (32 mg/kg), pimozide (2 mg/kg) or clozapine (40 mg/kg). Recovery of striatal DA after depletion by alpha-methyl-m-tyrosine (alpha MMT) (50 mg/kg) was facilitated by haloperidol (0.2 mg/kg) and sulpiride (32 mg/kg) but not by clozapine (40 mg/kg). The possibility that neuroleptic drugs antagonize both the short-term depletion of striatal DA produced by alpha MMT and the long-term depletion of striatal DA produced by amphetamine in iprindole-treated rats by an effect on the nerve impulse-mediated release of vesicular transmitter is discussed.
给经伊普吲哚（10mg/kg盐酸伊普吲哚）处理的大鼠腹腔注射单次剂量的（+）-硫酸苯丙胺（9.2mg/kg）后1周，纹状体多巴胺（DA）的减少可被氟哌啶醇（0.2mg/kg）、舒必利（32mg/kg）、匹莫齐特（2mg/kg）、盐酸氯丙嗪（3.5mg/kg）、盐酸氟奋乃静（0.25mg/kg）和（+）-盐酸布他拉莫（1mg/kg）阻止，但不能被（-）-盐酸布他拉莫（1mg/kg）或氯氮平（40mg/kg）阻止。相同剂量的舒必利并不能显著减弱给经伊普吲哚处理且有单侧纹状体抽吸损伤的大鼠注射（+）-硫酸苯丙胺（9.2mg/kg）所诱导的旋转行为。在给（+）-硫酸苯丙胺（9.2mg/kg）后8小时，经伊普吲哚处理的大鼠脑内苯丙胺的浓度不会因同时给予氟哌啶醇（1mg/kg）、舒必利（32mg/kg）、匹莫齐特（2mg/kg）或氯氮平（40mg/kg）而改变。α-甲基-m-酪氨酸（αMMT，50mg/kg）耗竭纹状体DA后，氟哌啶醇（0.2mg/kg）和舒必利（32mg/kg）可促进其恢复，但氯氮平（40mg/kg）则不能。文中讨论了抗精神病药物通过影响神经冲动介导的囊泡递质释放，拮抗αMMT在经伊普吲哚处理的大鼠中产生的纹状体DA短期耗竭以及苯丙胺产生的纹状体DA长期耗竭的可能性。
