Wagner G C, Ricaurte G A, Seiden L S, Schuster C R, Miller R J, Westley J
Brain Res. 1980 Jan 6;181(1):151-60. doi: 10.1016/0006-8993(80)91265-2.
Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.
反复给予高剂量甲基苯丙胺会导致大鼠纹状体中多巴胺（DA）水平和DA摄取位点数量长期下降。这两种效应与剂量相关，且似乎并非由于纹状体组织中药物的持续存在所致。甲基苯丙胺诱导的持久耗竭对纹状体DA神经元具有选择性，因为在所检查的所有大鼠脑区中，去甲肾上腺素（NE）水平并未因甲基苯丙胺处理而长期改变。DA受体超敏反应并未伴随纹状体DA及其摄取位点的丧失。
