Saad W A, Camargo L A, Saad W A
Pharmacology. 1984;28(4):228-34. doi: 10.1159/000137967.
The effects of sodium and potassium excretion after intrahypothalamic administration of two alpha-adrenoceptor agonists and the effect of alpha-adrenoceptor antagonists were studied in groups of rats. Prazosin was equally effective at blocking the natriuretic and kaliuretic responses to the alpha 1-adrenoceptor agonist phenylephrine and the mixed alpha 1/alpha 2-adrenoceptor agonist noradrenaline, while yohimbine which acts preferentially on alpha 2-adrenoceptors was effective in potentiating these responses. These results suggest the presence of two types of alpha-adrenoceptors for the modulation of ventromedial hypothalamic pathways that interfere with the regulation of the two cations: stimulation of alpha 1-adrenoceptors facilitates, while stimulation of alpha 2-adrenoceptors inhibits the excretion of the ions.
在几组大鼠中研究了下丘脑内注射两种α-肾上腺素能激动剂后钠和钾排泄的影响以及α-肾上腺素能拮抗剂的作用。哌唑嗪在阻断对α1-肾上腺素能激动剂去氧肾上腺素和混合α1/α2-肾上腺素能激动剂去甲肾上腺素的利钠和利钾反应方面同样有效，而优先作用于α2-肾上腺素能受体的育亨宾在增强这些反应方面有效。这些结果表明存在两种类型的α-肾上腺素能受体，用于调节下丘脑腹内侧通路，这些通路干扰两种阳离子的调节：刺激α1-肾上腺素能受体促进离子排泄，而刺激α2-肾上腺素能受体则抑制离子排泄。
