Saad W A, Camargo G P, Camargo L A
Department of Physiology, School of Dentistry, Paulista State University, Araraquara, Brazil.
Pharmacology. 1996 Nov;53(5):281-8. doi: 10.1159/000139440.
The effects of clonidine on sodium and potassium excretions were examined after previous administration of prazosin (an alpha 1-adrenergic receptor antagonist) and yohimbine (an alpha 2-adrenergic receptor antagonist) into the ventromedial nucleus of the hypothalamus of conscious rats. Clonidine injected into the ventromedial nucleus of the hypothalamus induced inhibitory and facilitatory effects on the urinary sodium and potassium excretions. The results suggest that facilitatory effects of clonidine on natriuresis and kaliuresis are mediated through activation of alpha 1-adrenoceptors and that inhibitory effects require alpha 2A-adrenoceptors.
在向清醒大鼠下丘脑腹内侧核预先注射哌唑嗪（一种α1肾上腺素能受体拮抗剂）和育亨宾（一种α2肾上腺素能受体拮抗剂）后，研究了可乐定对钠和钾排泄的影响。向下丘脑腹内侧核注射可乐定对尿钠和尿钾排泄产生抑制和促进作用。结果表明，可乐定对利钠和利钾的促进作用是通过激活α1肾上腺素能受体介导的，而抑制作用则需要α2A肾上腺素能受体。
