Cauda R, Miggiano G, Tamburrini E, Mordente A, Laghi V
Quad Sclavo Diagn. 1983 Jun;19(2):192-203.
The value of serum gamma-glutamyltransferase activity has been serially evaluated in 63 patients with acute viral hepatitis at four different periods of the disease (i.e. 0-10, 10-20, 20-30, 30-40 days from the onset of symptoms). The values of serum alanine-aminotransferase, serum alkaline phosphatase and total bilirubin have been evaluated in the same patients at the same period of time. At the first determination the gamma-glutamyltransferase activity was high in acute viral hepatitis, independently from aetiology (A, B, non-A, non-B), although the single values recorded in acute viral hepatitis type non-A, non-B, were higher than those observed in the other types. This activity exhibited a monoesponential pattern of decrease in all types of acute viral hepatitis; and it was still found high in the recovery phase when the others biohumoral indices (alanine-aminotransferase, alkaline phosphatase, total bilirubin) reached a normal level. Therefore gamma-glutamyltransferase activity could be considered of importance in the follow-up of acute viral hepatitis patients, although strictly in conjunction with alanine-aminotransferase, alkaline phosphatase determination.
对63例急性病毒性肝炎患者在疾病的四个不同时期（即症状出现后的0 - 10天、10 - 20天、20 - 30天、30 - 40天）连续评估血清γ-谷氨酰转移酶活性。在同一时期对这些患者的血清丙氨酸氨基转移酶、血清碱性磷酸酶和总胆红素值进行了评估。在首次测定时，急性病毒性肝炎患者的γ-谷氨酰转移酶活性较高，与病因（甲型、乙型、非甲型、非乙型）无关，尽管非甲型、非乙型急性病毒性肝炎记录的单个值高于其他类型。在所有类型的急性病毒性肝炎中，该活性呈现单指数下降模式；当其他生物体液指标（丙氨酸氨基转移酶、碱性磷酸酶、总胆红素）达到正常水平时，在恢复期仍发现其活性较高。因此，γ-谷氨酰转移酶活性在急性病毒性肝炎患者的随访中可能具有重要意义，尽管严格来说要与丙氨酸氨基转移酶、碱性磷酸酶测定相结合。
