Ingemarsson I, Liedholm H, Montan S, Westgren M, Melander A
Acta Obstet Gynecol Scand Suppl. 1984;118:95-7. doi: 10.3109/00016348409157132.
The effects of two different beta-adrenergic antagonists on maternal arterial pressure and fetal heart rate were studied in 8 pregnant women with pregnancy hypertension. The fetal heart rate was monitored by abdominal ECG recording under standardized conditions. Basal heart rate, long-term variability and short-term variability were calculated in a computer. Four patients received 50-100 mg atenolol once daily; the other 4 received pindolol 10 mg b.i.d. Reduction in mean arterial blood pressure was seen in both groups of patients. The basal fetal heart rate was decreased in atenolol-exposed fetuses but not in pindolol-exposed fetuses. In this preliminary study there was no apparent effect on the fetal heart rate variability.
在8名妊娠高血压孕妇中研究了两种不同的β-肾上腺素能拮抗剂对母体动脉血压和胎儿心率的影响。在标准化条件下通过腹部心电图记录监测胎儿心率。在计算机中计算基础心率、长期变异性和短期变异性。4例患者每天服用一次50-100mg阿替洛尔；另外4例患者每天服用两次10mg吲哚洛尔。两组患者的平均动脉血压均有所降低。暴露于阿替洛尔的胎儿基础心率降低，但暴露于吲哚洛尔的胎儿基础心率未降低。在这项初步研究中，对胎儿心率变异性没有明显影响。
