Montan S, Solum T, Sjöberg N O
Acta Obstet Gynecol Scand Suppl. 1984;118:99-102. doi: 10.3109/00016348409157133.
Forty term patients with pregnancy-induced hypertension were treated with the beta 1-adrenoceptor blocker atenolol (Tenormin R; ICI) for at least 7 days prior to parturition. The antenatal cardiotocography (CTG) was visually analysed before and during treatment. The mean basal fetal heart rate (FHR) decreased from 143 +/- 7 beats per minute (bpm) to 133 +/- 8 bpm. In 13.1% of the recordings in treated patients there was a decrease in long-term variability for a period of more than 20 minutes; this was observed in only 2.3% prior to treatment. The amplitude of the accelerations was reduced from 23 +/- 6 bpm to 18 +/- 4 bpm. It was demonstrated that atenolol affected antenatal CTG, and this has to be taken into consideration when interpreting antenatal CTG as one parameter for evaluation of fetal well-being.
四十名患有妊娠高血压的足月孕妇在分娩前至少7天接受了β1肾上腺素能受体阻滞剂阿替洛尔（Tenormin R；ICI）治疗。在治疗前和治疗期间对产前胎心监护（CTG）进行了视觉分析。平均基础胎心率（FHR）从每分钟143±7次心跳（bpm）降至133±8 bpm。在接受治疗的患者中，13.1%的记录显示长期变异性在超过20分钟的时间段内降低；而治疗前仅为2.3%。加速幅度从23±6 bpm降至18±4 bpm。结果表明，阿替洛尔会影响产前CTG，在将产前CTG作为评估胎儿健康状况的一个参数进行解读时必须考虑到这一点。
