Hunt P C, Cotton B R, Smith G
Anesth Analg. 1984 Jan;63(1):65-8. doi: 10.1213/00000539-198401000-00013.
The effects of pancuronium and atracurium on the lower esophageal sphincter pressure (LESP) were studied in 24 healthy patients anesthetized with 0.5% halothane in 66% nitrous oxide in oxygen. After pancuronium (0.1 mg X kg-1) given intravenously there was a significant increase in LESP from a control value of 36 +/- 4.0 cm H2O to 50 +/- 4.6 cm H2O at 1 min. This produced an increase in barrier pressure (BRP) from 26 +/- 3.7 cm H2O to 41 +/- 4.3 cm H2O. These changes were sustained for 5 min accompanied by a significant increase in arterial pressure and heart rate. Atracurium (0.6 mg X kg-1) had no cardiovascular effects and produced little changes in either LESP or BRP. The findings of this study suggest that pancuronium may be of benefit in a rapid sequence induction.
在24例用0.5%氟烷、66%氧化亚氮和氧气混合气体麻醉的健康患者中，研究了泮库溴铵和阿曲库铵对食管下括约肌压力（LESP）的影响。静脉注射泮库溴铵（0.1mg/kg）后，1分钟时LESP从对照值36±4.0cmH₂O显著升高至50±4.6cmH₂O。这使得屏障压（BRP）从26±3.7cmH₂O升高至41±4.3cmH₂O。这些变化持续5分钟，同时动脉压和心率显著升高。阿曲库铵（0.6mg/kg）对心血管系统无影响，对LESP或BRP的影响也很小。本研究结果提示，泮库溴铵可能有利于快速顺序诱导。
