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去窦主动脉神经支配大鼠黑质纹状体系统中酪氨酸羟化酶活性降低。

Reduced tyrosine hydroxylase activity in nigrostriatal system of sinoaortic-denervated rats.

作者信息

Alexander N, Hirata Y, Nagatsu T

出版信息

Brain Res. 1984 May 14;299(2):380-2. doi: 10.1016/0006-8993(84)90724-8.

DOI:10.1016/0006-8993(84)90724-8
PMID:6145496
Abstract

Tyrosine hydroxylase activity was measured in the caudate nucleus and substantia nigra (pars compacta) of sinoaortic-denervated (SAD) and sham-operated (SO) rats 3 days after operation. The SAD groups had approximately a 50%, statistically significant, reduction of enzyme activity in both regions and also a significant reduction of dopamine in caudate nucleus. These results suggest a probable link between cortico-somatomotor integration and neural input from arterial baroreceptor neural pathways.

摘要

术后3天,测定了去窦弓神经(SAD)大鼠和假手术(SO)大鼠尾状核和黑质(致密部)的酪氨酸羟化酶活性。SAD组两个区域的酶活性均有大约50%的统计学显著降低,尾状核中的多巴胺也显著减少。这些结果提示皮质 - 躯体运动整合与动脉压力感受器神经通路的神经输入之间可能存在联系。

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