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[工作环境空气中雷洛昔芬最大允许浓度的实验依据]

[Experimental substantiation of the maximum permissible concentration of Reglone in the air of a work environment].

作者信息

Baĭnova A, Vulcheva V

出版信息

Probl Khig. 1977;3:11-8.

PMID:614550
Abstract

Reglon (20 per cent dikwad dibromide) is an extensively used herbioide and desiccant. During acute and chronic inhalatory experiments on white rats, using 4--hour exposure to water aerosols, determination is made of the acute LC50 -- 83 mg/m3, of the acute threshold concentration - 9.9 mg/m3 acute substance, as well as of the chronic threshold concentration - 0.32 mg/m3. In all instances the clinical picture of intoxication is characterized by pulmonary lesion, and partial involvement of liver and kidneys. The computed zones of acute and chronic inhalatory toxicity warrant the assumption that no sequelae dueto herbicide cumulation in the organism should be expected. At safety coefficient 3, the authors propose 0.1 mg/m3 dikwad dibromide as a temporary limit of the maximum allowable concentration of reglon in the working environment air.

摘要

雷吉隆(20%二氯二溴乙烷)是一种广泛使用的除草剂和干燥剂。在对白鼠进行的急性和慢性吸入实验中,让其接触4小时的水雾,测定出急性半数致死浓度为83毫克/立方米,急性阈浓度为9.9毫克/立方米,慢性阈浓度为0.32毫克/立方米。在所有情况下,中毒的临床表现均以肺部病变以及肝脏和肾脏部分受累为特征。计算得出的急性和慢性吸入毒性区域表明,不应预期有机体内会因除草剂累积而产生后遗症。在安全系数为3时,作者提议将0.1毫克/立方米的二氯二溴乙烷作为雷吉隆在工作环境空气中的最大允许浓度的临时限值。

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