Johnston D L, Manyari D E, Kostuk W J
Can Med Assoc J. 1984 Jun 1;130(11):1449-55.
The efficacy of two beta-receptor antagonists, propranolol and pindolol, was compared with that of a calcium antagonist, verapamil, in the treatment of exertional angina pectoris in 22 men (mean age 51 years). The clinical response and left ventricular function were evaluated with treadmill exercise and with radionuclide ventriculography performed while the patient was at rest or exercising supine with a bicycle ergometer. All the treatments significantly prolonged exercise duration (p less than 0.001) and reduced the number of patients terminating treadmill exercise because of angina (p less than 0.05). The resting heart rate was decreased markedly (p less than 0.001) by propranolol but only slightly (p less than 0.05) by pindolol and verapamil. The left ventricular ejection fraction during rest was unchanged by any treatment, but that during exercise was improved (p less than 0.05) by all the treatments. Patients who failed to gain relief from angina with one of the drugs often responded to another, and adverse reactions occurring with one drug did not necessarily occur with another. In summary, pindolol and verapamil were safe and effective alternatives to propranolol in the treatment of the exertional angina pectoris of these patients.
对22名男性（平均年龄51岁）进行研究，比较了两种β受体拮抗剂（普萘洛尔和吲哚洛尔）与一种钙拮抗剂（维拉帕米）治疗劳力性心绞痛的疗效。通过平板运动试验以及在患者静息或仰卧位蹬自行车测力计运动时进行放射性核素心室造影来评估临床反应和左心室功能。所有治疗均显著延长了运动持续时间（p<0.001），并减少了因心绞痛而终止平板运动试验的患者数量（p<0.05）。普萘洛尔使静息心率显著降低（p<0.001），而吲哚洛尔和维拉帕米仅使其略有降低（p<0.05）。任何治疗均未改变静息时的左心室射血分数，但所有治疗均使运动时的左心室射血分数有所改善（p<0.05）。用一种药物未能缓解心绞痛的患者，换用另一种药物往往有效，而且一种药物出现的不良反应不一定会在另一种药物上出现。总之，在治疗这些患者的劳力性心绞痛方面，吲哚洛尔和维拉帕米是普萘洛尔安全有效的替代药物。
