In vitro study of frog (Rana ridibunda Pallas) interrenal function by use of a simplified perifusion system. VII. Lack of effect of somatostatin on angiotensin-induced corticosteroid production.

Somatostatin (SRIF), the somatotropin release inhibiting factor of the hypothalamus, has been reported to inhibit the production of angiotensin II (AII)-stimulated aldosterone in the rat adrenal glomerulosa cells. Since the interrenal of the frog is the homolog of mammalian adrenal zona glomerulosa, the effect of synthetic SRIF on perifused dice of Rana ridibunda was tested. Graded doses of SRIF did not modify the spontaneous production of corticosterone and aldosterone. The highest concentration of SRIF (10(-5) M) did not alter the stimulatory effect of the AII agonist [Sar1-Val5] AII upon corticosteroidogenesis. Thus, in apparent contradiction to recent findings in mammals, SRIF did not alter the effect of AII in the frog interrenal cell.