Naloxone reserves the inhibitory effects of dynorphin A on motor activity in the mouse.
作者信息
Ukai M, Yamada S, Kameyama T
出版信息
Pharmacol Biochem Behav. 1984 May;20(5):815-8. doi: 10.1016/0091-3057(84)90206-5.
PMID:6146145
Abstract
Dynorphin-(1-17) (dynorphin A) significantly reduced the linear locomotion, rearing and grooming behaviors in mice using a newly devised multi-dimensional behavioral analyser. The behaviors inhibited by dynorphin A were dose-dependently antagonized by prior treatment with naloxone. The results suggest that dynorphin A-induced behavioral depression is mediated via opioid receptors in the mouse brain.
摘要
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Naloxone reserves the inhibitory effects of dynorphin A on motor activity in the mouse.
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