大鼠肝脏中的色氨酸转氨酶活性。
Tryptophan aminotransferase activity in rat liver.
作者信息
Stanley J C, Nicholas A R, Dickson A J, Thompson I M, Pogson C I
出版信息
Biochem J. 1984 May 15;220(1):341-4. doi: 10.1042/bj2200341.
Abstract
By using an antiserum raised against rat liver tyrosine aminotransferase, it was shown that about 60% of tryptophan aminotransferase activity in rat liver extracts is catalysed by this enzyme. Induction of tryptophan aminotransferase activity by intraperitoneal injections of tryptophan or triamcinolone can be entirely attributed to the effects of these agents on tyrosine aminotransferase. The origin of the other 40% of tryptophan aminotransferase activity remains to be established. This activity increases after starvation for 48 h. It is unlikely that tryptophan transamination plays a quantitatively important role in the metabolism of tryptophan by the liver.
摘要
通过使用针对大鼠肝脏酪氨酸转氨酶产生的抗血清，研究表明大鼠肝脏提取物中约60%的色氨酸转氨酶活性由该酶催化。腹腔注射色氨酸或曲安西龙对色氨酸转氨酶活性的诱导作用可完全归因于这些试剂对酪氨酸转氨酶的影响。其余40%色氨酸转氨酶活性的来源尚待确定。饥饿48小时后，这种活性会增加。色氨酸转氨基作用在肝脏色氨酸代谢中不太可能发挥重要的定量作用。
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本文引用的文献
1
Induction of tyrosine-alpha-ketoglutarate transaminase in rat liver. I. Hormonal nature.大鼠肝脏中酪氨酸-α-酮戊二酸转氨酶的诱导。I. 激素性质。
J Biol Chem. 1961 Oct;236:2699-702.
2
STUDIES ON THE SPECIFICITY OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE.酪氨酸-α-酮戊二酸转氨酶特异性的研究
J Biol Chem. 1964 Feb;239:419-24.
3
The glutathione-dependent indolylpyruvic acid keto-enol tautomerase of rat liver.
Arch Biochem Biophys. 1962 Jan;96:115-24. doi: 10.1016/0003-9861(62)90459-9.
4
Pattern of adaptive control of levels of rat liver tryptophan transaminase.大鼠肝脏色氨酸转氨酶水平的适应性控制模式
Science. 1959 Jun 19;129(3364):1672-3. doi: 10.1126/science.129.3364.1672.
5
Specificity of the adaptive response to tyrosine-alpha-ketoglutarate transaminase in the rat.大鼠对酪氨酸-α-酮戊二酸转氨酶适应性反应的特异性
J Biol Chem. 1958 Nov;233(5):1186-9.
6
7
The assay of aromatic amino acid transaminations and keto acid oxidation by the enol borate-tautomerase method.用烯醇硼酸互变异构酶法测定芳香族氨基酸转氨作用和酮酸氧化作用
J Biol Chem. 1958 Sep;233(3):668-73.
8
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J Biol Chem. 1967 Jan 25;242(2):173-81.
9
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J Biol Chem. 1972 Apr 25;247(8):2486-92.
10
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