Stanley J C, Nicholas A R, Dickson A J, Thompson I M, Pogson C I
Biochem J. 1984 May 15;220(1):341-4. doi: 10.1042/bj2200341.
By using an antiserum raised against rat liver tyrosine aminotransferase, it was shown that about 60% of tryptophan aminotransferase activity in rat liver extracts is catalysed by this enzyme. Induction of tryptophan aminotransferase activity by intraperitoneal injections of tryptophan or triamcinolone can be entirely attributed to the effects of these agents on tyrosine aminotransferase. The origin of the other 40% of tryptophan aminotransferase activity remains to be established. This activity increases after starvation for 48 h. It is unlikely that tryptophan transamination plays a quantitatively important role in the metabolism of tryptophan by the liver.
通过使用针对大鼠肝脏酪氨酸转氨酶产生的抗血清，研究表明大鼠肝脏提取物中约60%的色氨酸转氨酶活性由该酶催化。腹腔注射色氨酸或曲安西龙对色氨酸转氨酶活性的诱导作用可完全归因于这些试剂对酪氨酸转氨酶的影响。其余40%色氨酸转氨酶活性的来源尚待确定。饥饿48小时后，这种活性会增加。色氨酸转氨基作用在肝脏色氨酸代谢中不太可能发挥重要的定量作用。
