利用多普勒超声技术研究异丙肾上腺素和β-肾上腺素能受体阻断药对人体外周血管的作用。
The use of Doppler ultrasound techniques to study the effects of isoprenaline and beta-adrenoceptor blocking drugs on peripheral blood vessels in man.
作者信息
Fitzgerald D E, Harry J D
出版信息
Br J Clin Pharmacol. 1984 Jun;17(6):773-6. doi: 10.1111/j.1365-2125.1984.tb02418.x.
A Doppler ultrasound technique has been used in six volunteers to determine the effects of intravenous isoprenaline on blood velocity and volume blood flow in the femoral artery and to investigate the effects of single oral doses of atenolol (50 mg) and propranolol (40 mg) on these effects and on heart rate changes. Isoprenaline increased the blood velocity and volume blood flow which was attenuated by propranolol and not by atenolol; the tachycardia of isoprenaline was inhibited by both drugs. The results show that the Doppler ultrasound measurements in the femoral artery can identify pharmacologically induced changes in peripheral blood vessels in the leg and warrants further investigation as a tool to study the pharmacology of peripheral blood vessels in man.
一种多普勒超声技术已应用于6名志愿者，以确定静脉注射异丙肾上腺素对股动脉血流速度和血流量的影响，并研究单次口服阿替洛尔（50毫克）和普萘洛尔（40毫克）对这些影响以及心率变化的作用。异丙肾上腺素增加了血流速度和血流量，普萘洛尔可减弱这种作用，而阿替洛尔则无此作用；两种药物均可抑制异丙肾上腺素引起的心动过速。结果表明，股动脉的多普勒超声测量能够识别药理学诱导的腿部外周血管变化，作为研究人体外周血管药理学的工具值得进一步研究。
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