Pringle T H, Riddell J G, Shanks R G
Department of Therapeutics and Pharmacology, Queen's University of Belfast, Northern Ireland.
Eur J Clin Pharmacol. 1988;35(5):507-14. doi: 10.1007/BF00558246.
We have studied the contribution of beta 1- and beta 2-adrenoceptors to the isoprenaline-induced changes in heart rate, blood pressure, forearm blood flow, peripheral vascular resistance, and finger tremor. This was achieved by a comparison of the effects of atenolol 50 mg, ICI 118551 25 mg, propranolol 80 mg, atenolol 50 mg combined with ICI 118551 25 mg, propranolol 80 mg combined with ICI 118551 25 mg, and placebo. Atenolol 50 mg and ICI 118551 25 mg caused similar attenuations in the isoprenaline-induced changes in heart rate and diastolic blood pressure, but the responses after the combination of atenolol and ICI 118551 were similar to those after propranolol 80 mg. There was no difference in the forearm blood flow responses to isoprenaline after atenolol 50 mg and ICI 118551, but atenolol 50 mg did not reduce peripheral vascular resistance compared with placebo. Both responses after treatment with atenolol combined with ICI 118551 were similar to those after propranolol 80 mg. Finger tremor responses to isoprenaline were antagonized by ICI 118551 alone and in combination with propranolol and atenolol but not by atenolol alone, suggesting that the response is beta 2-adrenoceptor-mediated. We conclude that the cardiovascular responses to isoprenaline are mediated by both beta 1- and beta 2-adrenoceptors, whereas the finger tremor response is mediated by beta 2-adrenoceptors.
我们研究了β1和β2肾上腺素能受体对异丙肾上腺素引起的心率、血压、前臂血流量、外周血管阻力和手指震颤变化的作用。通过比较50mg阿替洛尔、25mg ICI 118551、80mg普萘洛尔、50mg阿替洛尔联合25mg ICI 118551、80mg普萘洛尔联合25mg ICI 118551以及安慰剂的效果来实现这一目的。50mg阿替洛尔和25mg ICI 118551对异丙肾上腺素引起的心率和舒张压变化产生了相似的减弱作用，但阿替洛尔与ICI 118551联合使用后的反应与80mg普萘洛尔后的反应相似。50mg阿替洛尔和ICI 118551对异丙肾上腺素引起的前臂血流量反应没有差异，但与安慰剂相比，50mg阿替洛尔并未降低外周血管阻力。阿替洛尔与ICI 118551联合治疗后的两种反应均与80mg普萘洛尔后的反应相似。单独使用ICI 118551以及与普萘洛尔和阿替洛尔联合使用时可拮抗手指对异丙肾上腺素的震颤反应，但单独使用阿替洛尔则不能，这表明该反应是由β2肾上腺素能受体介导的。我们得出结论，对异丙肾上腺素的心血管反应由β1和β2肾上腺素能受体介导，而手指震颤反应由β2肾上腺素能受体介导。
