Porotikov V I, Cherenshchikova E A, Filippov A K, Mashkovskiĭ M D, Iuzhakov S D
Biull Eksp Biol Med. 1984 Jun;97(6):677-9.
The effects of propranolol, oxprenolol, pindolol, labetalol, and atenolol on the isoproterenol-stimulated slow calcium current as well as on spontaneous slow calcium and fast sodium currents were studied in frog trabeculae by the double sucrose bridge technique. Administration of beta-adrenoblockers in low doses (10(-7)-10(-6)M) antagonized the stimulatory effect of isoproterenol on the slow calcium current (pindolol greater than oxprenolol greater than or equal to propranolol = labetalol greater than atenolol). When administered in high doses (2 X 10(-6)-10(-4)M) the beta-adrenoblockers reduced the slow calcium current. Meanwhile, some of them (propranolol, oxprenolol, labetalol) suppressed the fast sodium current.
采用双蔗糖桥技术，在蛙小梁中研究了普萘洛尔、氧烯洛尔、吲哚洛尔、拉贝洛尔和阿替洛尔对异丙肾上腺素刺激的慢钙电流以及自发性慢钙电流和快钠电流的影响。低剂量（10⁻⁷ - 10⁻⁶M）的β-肾上腺素能阻滞剂给药可拮抗异丙肾上腺素对慢钙电流的刺激作用（吲哚洛尔＞氧烯洛尔≥普萘洛尔 = 拉贝洛尔＞阿替洛尔）。当高剂量（2×10⁻⁶ - 10⁻⁴M）给药时，β-肾上腺素能阻滞剂可降低慢钙电流。同时，其中一些药物（普萘洛尔、氧烯洛尔、拉贝洛尔）可抑制快钠电流。
