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Glucose utilization in the auditory system: cochlear dysfunctions and species differences.

作者信息

Canlon B, Takada A, Schacht J

出版信息

Comp Biochem Physiol A Comp Physiol. 1984;78(1):43-7. doi: 10.1016/0300-9629(84)90089-6.

DOI:10.1016/0300-9629(84)90089-6
PMID:6146437
Abstract

Deoxyglucose uptake in peripheral auditory tissues and inferior colliculus of the young CBA or C57BL/6J mouse increases with intensity of an acoustic stimulus from 25 to 85 dBA and decreases from 85 to 115 dBA. In 36-month-old CBA and 9-month-old C57BL with sensorineural hearing loss the metabolic response to stimulation is attenuated 50% or more. Metabolic responses to stimuli are qualitatively and quantitatively different in the gerbil and in the guinea-pig. It is concluded that cochlear dysfunctions are characterized by abnormal evoked metabolism; and that the stimulus-response pattern varies with species.

摘要

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