Vinardell M P, Bendahan G
Comp Biochem Physiol A Comp Physiol. 1984;78(2):363-6. doi: 10.1016/0300-9629(84)90161-0.
The effects of L-leucine on jejunal and ileal D-galactose absorption have been studied at three different ages in rats using a perfusion system in vivo. Both, D-galactose and L-leucine have been perfused through the jejunum and the ileum at two concentrations, 5mM (low) and 20 mM (high). L-leucine induced a reversible inhibition of D-galactose absorption at the three ages studied and in both intestinal segments. The inhibition was higher at 20 mM when carriers were saturated. A lineal correlation exits between the inhibition percentage and the age of animals, increasing with growth in the jejunum and decreasing in the ileum. Attention is called to the possibility of different transport mechanisms at low concentration (5 mM), one of low affinity in the jejunum and the other of high affinity in the ileum.
利用体内灌注系统，研究了L-亮氨酸对不同年龄大鼠空肠和回肠D-半乳糖吸收的影响。D-半乳糖和L-亮氨酸均以5mM（低浓度）和20mM（高浓度）两种浓度通过空肠和回肠进行灌注。在所研究的三个年龄段以及两个肠段中，L-亮氨酸均诱导了D-半乳糖吸收的可逆性抑制。当载体饱和时，20mM浓度下的抑制作用更强。抑制百分比与动物年龄之间存在线性相关性，在空肠中随生长增加，在回肠中随生长降低。需要注意的是，在低浓度（5mM）下可能存在不同的转运机制，一种在空肠中亲和力低，另一种在回肠中亲和力高。
