从大蜡螟中分离出的生物活性物质对培养的椎实螺神经元的影响。

Influence of biologically active substances isolated from Galleria mellonella on neurons of Lymnaea stagnalis in culture.

作者信息

Spiridonov N A, Kostenko M A, Volkova S P, Pogorelov A G, Kondrashova M N

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;78(1):207-10. doi: 10.1016/0742-8413(84)90071-9.

Abstract

A procedure for isolating biologically active substances from Galleria mellonella using a culture of isolated giant neurons of mollusc Lymnaea stagnalis as a test-system is described. Fractions capable of activating neurites and inhibiting aggregation of neuronal cells within a range of concentrations from 1 to 30 micrograms/ml were isolated. The fractions obtained have in their chemical composition about 10.5% N, also contain P and S. They have a carbohydrate component.

摘要

描述了一种使用蛞蝓（Lymnaea stagnalis）分离的巨型神经元培养物作为测试系统从大蜡螟（Galleria mellonella）中分离生物活性物质的方法。分离出了在1至30微克/毫升浓度范围内能够激活神经突并抑制神经元细胞聚集的组分。所获得的组分在其化学组成中约含10.5%的氮，还含有磷和硫。它们具有碳水化合物成分。