Kasanuki J, Fujimoto S, Makino H, Kanatsuka A, Imaizumi T, Koseki H, Kaneko R, Tokumasa Y, Yoshida S
Gastroenterol Jpn. 1984 Jun;19(3):221-6. doi: 10.1007/BF02779173.
The effect of administration of synthetic caerulein on canine plasma somatostatin concentration in the portal vein was investigated using specific radioimmunoassay of acid-acetone extracted plasma. Gel chromatography revealed that the main component of the plasma somatostatin in the portal vein was identical with somatostatin-14. After administration of caerulein (5 ng/kg), the somatostatin level increased significantly while the gastrin level remained unchanged. These results suggested that caerulein affects D cell function but not gastrin secretion.
采用酸丙酮提取血浆的特异性放射免疫分析法，研究了合成蛙皮素给药对犬门静脉血浆生长抑素浓度的影响。凝胶色谱法显示，门静脉血浆生长抑素的主要成分与生长抑素-14相同。给予蛙皮素（5纳克/千克）后，生长抑素水平显著升高，而胃泌素水平保持不变。这些结果表明，蛙皮素影响D细胞功能，但不影响胃泌素分泌。
