对清醒家兔静脉注射假定的α1和α2肾上腺素能受体激动剂后的升压反应进行分析。
An analysis of the pressor responses to putative alpha 1 and alpha 2-adrenoreceptor agonists given intravenously to conscious rabbits.
作者信息
Hannah J A, Hamilton C A, Reid J L
出版信息
J Auton Pharmacol. 1984 Jun;4(2):73-6. doi: 10.1111/j.1474-8673.1984.tb00083.x.
The selectivity of a range of alpha 1 and alpha 2-adrenoreceptor agonists was examined in the conscious rabbit. In this preparation the pressor responses to BHT 920, BHT 933, guanabenz and alpha-methylnoradrenaline were attenuated by idazoxan but not by prazosin. The pressor responses to clonidine and noradrenaline were attenuated by both idazoxan and prazosin while the response to phenylephrine was only significantly attenuated by prazosin. Both an immediate pressor response and a later depressor response to clonidine was observed but there were no depressor components to either BHT 920 or BHT 933 responses. Pressor responses to guanabenz were attenuated on repeated dosing.
在清醒兔中检测了一系列α1和α2肾上腺素能受体激动剂的选择性。在该实验准备中，对BHT 920、BHT 933、胍法辛和α-甲基去甲肾上腺素的升压反应可被咪唑克生减弱，但不能被哌唑嗪减弱。对可乐定和去甲肾上腺素的升压反应可被咪唑克生和哌唑嗪均减弱，而对去氧肾上腺素的反应仅被哌唑嗪显著减弱。观察到对可乐定有即刻升压反应和随后的降压反应，但对BHT 920或BHT 933的反应均无降压成分。重复给药后，对胍法辛的升压反应减弱。
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