托酚酮对左旋多巴诱导的大鼠下丘脑S-腺苷同型半胱氨酸与S-腺苷甲硫氨酸比值升高的拮抗作用：而非肾上腺素耗竭作用。
Tropolone antagonism of the L-dopa-induced elevation of S-adenosylhomocysteine: S-adenosylmethionine ratio but not depletion of adrenaline in rat hypothalamus.
作者信息
Fuller R W, Perry K W, Hemrick-Leucke S K
出版信息
J Pharm Pharmacol. 1984 Jun;36(6):419-20. doi: 10.1111/j.2042-7158.1984.tb04416.x.
Abstract
Tropolone, an inhibitor of catechol O-methyl transferase, largely prevented the increase in SAH : SAMe ratio in rat hypothalamus following L-dopa injection. Tropolone did not prevent but instead enhanced the decrease produced by L-dopa of adrenaline concentration in rat hypothalamus. The results imply that the decrease in hypothalamic adrenaline concentration following L-dopa injection was not caused by the increase in SAH : SAMe ratio.
摘要
儿茶酚-O-甲基转移酶抑制剂托酚酮在很大程度上阻止了左旋多巴注射后大鼠下丘脑SAH:SAMe比值的升高。托酚酮并未阻止反而增强了左旋多巴导致的大鼠下丘脑肾上腺素浓度的降低。这些结果表明，左旋多巴注射后下丘脑肾上腺素浓度的降低并非由SAH:SAMe比值的升高所致。
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