Sitsen J M, Nijkamp F P
J Pharm Pharmacol. 1984 Jul;36(7):481-3. doi: 10.1111/j.2042-7158.1984.tb04433.x.
At an ambient temperature of 21 degrees C alpha-methyldopa (25-200 mg kg-1) induces a dose-dependent decrease in body temperature in rats. A relationship between adrenergic and opioid neuronal systems has been reported. Therefore, in this study the hypothesis that alpha-methyldopa produces hypothermia through release of endogenous opioid peptides has been investigated using the opiate antagonist naltrexone. The hypothermic effect of alpha-methyldopa is potentiated by naltrexone pointing to antagonism of an hyperthermic acting opioid system. However, at an ambient temperature of 6 degrees C, pretreatment with naltrexone did not significantly alter the hypothermic effect of alpha-methyldopa. Although the hypothesis proved not to be correct, it is concluded that depending on ambient temperature opioid peptides are involved in the determination of the ultimate effect of alpha-methyldopa on body temperature in rats.
在21摄氏度的环境温度下，α-甲基多巴（25 - 200毫克/千克）可使大鼠体温呈剂量依赖性下降。已有报道表明肾上腺素能和阿片样物质神经元系统之间存在关联。因此，在本研究中，使用阿片拮抗剂纳曲酮对α-甲基多巴通过释放内源性阿片肽产生体温过低这一假说进行了研究。纳曲酮增强了α-甲基多巴的体温过低效应，表明其对具有升温作用的阿片系统具有拮抗作用。然而，在6摄氏度的环境温度下，用纳曲酮预处理并未显著改变α-甲基多巴的体温过低效应。尽管该假说被证明是不正确的，但得出的结论是，根据环境温度，阿片肽参与了α-甲基多巴对大鼠体温最终影响的决定过程。
