Perera M I, Shinozuka H
Carcinogenesis. 1984 Sep;5(9):1193-8. doi: 10.1093/carcin/5.9.1193.
Enzyme altered preneoplastic hepatocyte foci were induced in male Sprague Dawley rats by a single injection of diethylnitrosamine (DEN) followed by dietary promotion of a choline-deficient (CD) diet for 4 weeks or by feeding a diet containing 0.02% 2-acetylaminofluorene for 4 weeks. BR931, a hypolipidemic agent, administered to rats bearing preneoplastic foci caused a rapid regression of the foci within 4-6 weeks. Di(2-ethylhexyl)phthalate (DEHP), a plasticiser, exerted the similar effect when tested on rats bearing preneoplastic foci induced by DEN + CD diet. Since BR931 and DEHP have been shown to be carcinogenic after long term feeding, the results suggest that the short-term effects of the class of agents known as hypolipidemic peroxisome proliferators are different from the chronic effects. Alternatively, the precursor lesions of hepatocellular carcinomas induced by hypolipidemic, peroxisome proliferators may differ from enzyme altered hepatocytic foci.
通过单次注射二乙基亚硝胺（DEN），随后用胆碱缺乏（CD）饮食进行4周的饮食促进，或通过喂食含0.02% 2-乙酰氨基芴的饮食4周，在雄性斯普拉格-道利大鼠中诱导出酶改变的癌前肝细胞灶。给患有癌前病灶的大鼠施用降血脂剂BR931，可使病灶在4至6周内迅速消退。邻苯二甲酸二（2-乙基己基）酯（DEHP），一种增塑剂，在对由DEN + CD饮食诱导的癌前病灶大鼠进行测试时也有类似效果。由于BR931和DEHP长期喂食后已被证明具有致癌性，结果表明，称为降血脂过氧化物酶体增殖剂的这类药物的短期作用与长期作用不同。或者，降血脂过氧化物酶体增殖剂诱导的肝细胞癌的前体病变可能与酶改变的肝细胞灶不同。
