Nair K S, Halliday D, Garrow J S
Diabetologia. 1984 Jul;27(1):13-6. doi: 10.1007/BF00253494.
The basal energy expenditure of 10 Type 1 (insulin-dependent) C-peptide-negative diabetic patients (2042 +/- 62 kcal/24 h) was found to be significantly higher than the 1774 +/- 52 kcal/24 h predicted from their age, sex and body surface area (p less than 0.01). Intravenous insulin treatment significantly reduced energy expenditure to 1728 +/- 19 kcal/24h (p less than 0.01), which matched predicted values. The observed increase in metabolic rate in uncontrolled diabetic patients is associated with increased protein turnover, increased plasma glucagon, but no significant increase in cortisol, growth hormone or triiodothyronine concentrations in plasma. It may be accounted for by the energy cost of protein synthesis, or gluconeogenesis, or possibly increased sympathetic activity. This increased energy expenditure will contribute to the weight loss seen in Type 1 diabetic patients.
10名1型（胰岛素依赖型）C肽阴性糖尿病患者的基础能量消耗为（2042±62千卡/24小时），发现显著高于根据其年龄、性别和体表面积预测的1774±52千卡/24小时（p<0.01）。静脉注射胰岛素治疗可使能量消耗显著降低至1728±19千卡/24小时（p<0.01），与预测值相符。在未得到控制的糖尿病患者中观察到的代谢率增加与蛋白质周转增加、血浆胰高血糖素升高有关，但血浆皮质醇、生长激素或三碘甲状腺原氨酸浓度无显著增加。这可能是由蛋白质合成或糖异生的能量消耗引起的，也可能是交感神经活动增加所致。这种增加的能量消耗将导致1型糖尿病患者体重减轻。
