Sasaki D, Kido A, Yoshida Y
Int J Clin Pharmacol Ther Toxicol. 1984 Jul;22(7):333-7.
The inhibitory effect of five antispasmodic preparations, prifinium bromide, hyoscine butylbromide, propinox, trimebutine maleate and phloroglucinol + trimethyl-phloroglucinol on acetylcholine-induced contraction of the colon was investigated in anesthetized dogs. Prifinium bromide was most potent followed by hyoscine butylbromide. The other three preparations had no potent inhibitory effect even when given in a dose of 1000 micrograms/kg. The ED50 was 3.1 micrograms/kg for prifinium bromide and 12.3 micrograms/kg for hyoscine butylbromide; the prolonged time of action at ED50 was approximately 30 minutes for prifinium bromide and about 10 minutes for hyoscine butylbromide. From the dog experiments, it became clear that prifinium bromide and hyoscine butylbromide had a relatively potent antispasmodic effect on the colon.
在麻醉犬身上研究了五种解痉制剂，即溴丙胺太林、丁溴东莨菪碱、丙哌苯丙酮、马来酸曲美布汀和间苯三酚+三甲基间苯三酚对乙酰胆碱诱导的结肠收缩的抑制作用。溴丙胺太林的效力最强，其次是丁溴东莨菪碱。其他三种制剂即使以1000微克/千克的剂量给药也没有强效的抑制作用。溴丙胺太林的半数有效量（ED50）为3.1微克/千克，丁溴东莨菪碱为12.3微克/千克；在ED50时，溴丙胺太林的作用持续时间延长约30分钟，丁溴东莨菪碱约为10分钟。从犬实验中可以清楚地看出，溴丙胺太林和丁溴东莨菪碱对结肠具有相对强效的解痉作用。
