Sasaki D, Kido A, Yoshida Y
Int J Clin Pharmacol Ther Toxicol. 1984 Jul;22(7):338-41.
Four antispasmodic preparations (prifinium bromide, propinox, trimebutine maleate and phloroglucinol + trimethylphloroglucinol) identical to those in Part I, study of the dog, were used. Eight subjects were tested for each preparation and eight subjects for the control. The inhibitory effect of the test preparations on neostigmine-induced hypermotility of the ascending and sigmoid colons were investigated. Prifinium bromide provided a marked antispasmodic effect on the ascending and sigmoid colons; the inhibitory effect of trimebutine maleate was limited to the ascending colon. Propinox and phloroglucinol + trimethylphloroglucinol possessed no clear action. It is estimated that prifinium bromide may be useful in the control of the manifestic state of hypermotility of the colon.
使用了四种与第一部分狗实验中相同的解痉制剂（溴化普里芬铵、丙哌卡因、马来酸曲美布汀和间苯三酚+三甲基间苯三酚）。每种制剂测试8名受试者，8名受试者作为对照。研究了受试制剂对新斯的明诱导的升结肠和乙状结肠运动亢进的抑制作用。溴化普里芬铵对升结肠和乙状结肠有明显的解痉作用；马来酸曲美布汀的抑制作用仅限于升结肠。丙哌卡因和间苯三酚+三甲基间苯三酚没有明显作用。据估计，溴化普里芬铵可能有助于控制结肠运动亢进的表现状态。
