Armstrong J A, Horne R
Lancet. 1984 Aug 18;2(8399):370-2. doi: 10.1016/s0140-6736(84)90540-3.
Follicular labyrinthine foci, consisting of an association of retrovirus-like particles with expanded dendritic reticular ("antigen trapping") cells, are described in lymph nodes from four immunodeficient homosexual men with unexplained persistent lymphadenopathy. One patient has severe acquired immunodeficiency syndrome (AIDS) with complicating Pneumocystis carinii infection, and the others have AIDS-related lymphadenopathy syndrome. The findings support a role for routine electron microscopy as an aid to diagnostic evaluation of nodal tissue from patients with suspected AIDS. Viral non-lymphoid-cell tropism may be a significant factor in the pathogenesis of the disease.
在四名患有无法解释的持续性淋巴结病的免疫缺陷同性恋男性的淋巴结中，发现了滤泡性迷宫样病灶，其由逆转录病毒样颗粒与扩大的树突状网状（“抗原捕获”）细胞组成。一名患者患有严重的获得性免疫缺陷综合征（AIDS）并伴有卡氏肺孢子虫感染，其他患者患有艾滋病相关淋巴结病综合征。这些发现支持常规电子显微镜检查在疑似艾滋病患者淋巴结组织诊断评估中的作用。病毒的非淋巴细胞嗜性可能是该疾病发病机制中的一个重要因素。
