Peters W H, Gottschling D, Ziegler M, Haude W
Acta Biol Med Ger. 1977;36(9):1343-6.
Basal plasma insulin levels were measured in Wistar-rats rendered obese by feeding a high-fat diet (50% fat, w/w). During the period of rapid weight-gaining ("dynamic phase" of the development of obesity) fat-fed rats show elevated basal insulin levels in the peripheral blood plasma. No further enhancement occurred in the so-called "static phase" of obesity. Changing the feeding schedule at 20 weeks of age, e.g. feeding control diets (3% fat, w/v) for 4 weeks to fatty rats, results in a depression of insulin levels to control values together with a reduction of the body weight. The findings are discussed in relation to the dietary induced alterations of carbohydrate and lipid metabolism of obese rats.
通过喂食高脂饮食（50%脂肪，w/w）使Wistar大鼠肥胖，然后测量其基础血浆胰岛素水平。在快速增重期（肥胖发展的“动态期”），高脂喂养的大鼠外周血浆中的基础胰岛素水平升高。在肥胖的所谓“静态期”未出现进一步升高。在20周龄时改变喂食方案，例如给肥胖大鼠喂食4周对照饮食（3%脂肪，w/v），会导致胰岛素水平降至对照值，同时体重减轻。结合饮食诱导的肥胖大鼠碳水化合物和脂质代谢变化对这些发现进行了讨论。
