Davison J M, Sprott M S, Selkon J B
Lancet. 1984 Sep 22;2(8404):651-5. doi: 10.1016/s0140-6736(84)91222-4.
Schoolgirls shown to have covert bacteriuria (CB) by a screening programme and followed up for 5 years to assess whether chemotherapy had any beneficial effect, underwent a further assessment of renal function at the age of 18 years and during subsequent pregnancies. At age 18, glomerular filtration rate (GFR) and urine concentrating ability were the same as in controls, but fractional reabsorption of glucose was significantly reduced in those who had previously been prescribed chemotherapy because of renal scarring or who had been randomly allocated not to receive prophylactic chemotherapy. Those who had had CB as schoolgirls had a higher frequency of CB in pregnancy than did controls, whether or not prophylactic chemotherapy had been given to the subjects when they were schoolgirls. Furthermore, compared with girls who had had such treatment, untreated patients had smaller increments in GFR, reduced fractional reabsorption of glucose, and more than usual degree of glycosuria during pregnancy. This suggests that subclinical renal damage may be prevented by prophylactic chemotherapy but this advantage is unmasked only by the physiological demands of pregnancy.
通过筛查项目显示患有隐匿性菌尿（CB）的女学生被随访5年，以评估化疗是否有任何有益效果，她们在18岁时以及随后的孕期接受了进一步的肾功能评估。18岁时，肾小球滤过率（GFR）和尿液浓缩能力与对照组相同，但因肾瘢痕曾接受化疗或被随机分配未接受预防性化疗的患者，其葡萄糖的分数重吸收显著降低。曾在女童期患CB的女性在孕期患CB的频率高于对照组，无论她们在女童期是否接受过预防性化疗。此外，与接受过此类治疗的女孩相比，未治疗的患者在孕期GFR的增加较小，葡萄糖的分数重吸收减少，且糖尿程度高于平常。这表明预防性化疗可能预防亚临床肾损伤，但这种优势仅在孕期的生理需求下才会显现出来。
