大肠杆菌1型菌毛亚基的分泌与组装对正常蛋白质输出的依赖性
Dependence of secretion and assembly of type 1 fimbrial subunits of Escherichia coli on normal protein export.
作者信息
Dodd D C, Bassford P J, Eisenstein B I
出版信息
J Bacteriol. 1984 Sep;159(3):1077-9. doi: 10.1128/jb.159.3.1077-1079.1984.
Abstract
The export of fimbrial subunits was found to be diminished at the restrictive temperature in a strain bearing a secA(Ts) mutation. Likewise, export was inhibited in a strain harboring a malE-lacZ protein fusion upon induction of hybrid protein synthesis. Both conditions resulted in the accumulation of a precursor protein ca. 2,000 daltons larger than the mature fimbrial subunit.
摘要
在携带secA（Ts）突变的菌株中，发现菌毛亚基的输出在限制温度下减少。同样，在诱导杂交蛋白合成后，含有malE-lacZ蛋白融合体的菌株中输出受到抑制。这两种情况都导致一种前体蛋白积累，该前体蛋白比成熟菌毛亚基大约2000道尔顿。
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