Myhre E S, Sørlie D, Aarbakke J, Hals P A, Straume B
J Cardiovasc Surg (Torino). 1984 Jul-Aug;25(4):348-52.
This study was performed to record the occurrence of clinically important supraventricular tachyarrhythmias (SVA) during the first eight days following coronary bypass surgery after preoperative withdrawal of various betablockers and to investigate whether low dose propranolol medication postoperatively could reduce the occurrence of such arrhythmias. Forty patients with stable angina pectoris were postoperatively randomly assigned to either a group (B) receiving low doses of propranolol or to a group (A) not receiving this medication. The number of patients having episodes of clinically important SVA was recorded. Two out of sixteen patients in the propranolol group had such episodes compared with nine out of twenty without postoperative betablockade (p = 0.07). Thus among patients treated with various betablockers which were withdrawn prior to coronary surgery, the occurrence of postoperative clinically important SVA could not be significantly reduced by postoperative low dose propranolol administration.
本研究旨在记录冠状动脉搭桥手术后头八天内，术前停用各种β受体阻滞剂后临床上重要的室上性快速心律失常（SVA）的发生情况，并研究术后低剂量普萘洛尔用药是否能减少此类心律失常的发生。40例稳定型心绞痛患者术后被随机分为两组，一组（B组）接受低剂量普萘洛尔治疗，另一组（A组）不接受该药物治疗。记录发生临床上重要SVA发作的患者数量。普萘洛尔组16例患者中有2例出现此类发作，而术后未使用β受体阻滞剂的20例患者中有9例出现此类发作（p = 0.07）。因此，在冠状动脉手术前停用各种β受体阻滞剂治疗的患者中，术后给予低剂量普萘洛尔并不能显著降低临床上重要的术后SVA的发生率。
