乙酰胆碱和儿茶酚胺对培养的胸腺淋巴细胞有丝分裂的促进作用。

The promotion of mitosis in cultured thymic lymphocytes by acetylcholine and catecholamines.

作者信息

Morgan J I, Wigham C G, Perris A D

出版信息

J Pharm Pharmacol. 1984 Aug;36(8):511-5. doi: 10.1111/j.2042-7158.1984.tb04441.x.

DOI:10.1111/j.2042-7158.1984.tb04441.x

Abstract

Thymic lymphoblasts possess beta-adrenergic, dopaminergic and nicotinic receptors. When activated by high concentrations of adrenaline, isoprenaline, dopamine and acetylcholine, magnesium-dependent events are initiated, which culminate in mitosis. These events can be blocked by testosterone. The cells also possess muscarinic and alpha-adrenergic receptors which respond to low concentrations of acetylcholine, carbamylcholine and noradrenaline. In these cases calcium-dependent, oestradiol-blockable mechanisms are triggered which eventually lead to cell division.

摘要

胸腺淋巴母细胞拥有β-肾上腺素能、多巴胺能和烟碱样受体。当被高浓度的肾上腺素、异丙肾上腺素、多巴胺和乙酰胆碱激活时，会启动依赖镁的事件，最终导致有丝分裂。这些事件可被睾酮阻断。这些细胞还拥有毒蕈碱样和α-肾上腺素能受体，它们对低浓度的乙酰胆碱、氨甲酰胆碱和去甲肾上腺素作出反应。在这些情况下，会触发依赖钙的、可被雌二醇阻断的机制，最终导致细胞分裂。