Bellinger Denise L, Millar Brooke A, Perez Sam, Carter Jeff, Wood Carlo, ThyagaRajan Srinivasan, Molinaro Christine, Lubahn Cheri, Lorton Dianne
Department of Pathology & Human Anatomy, Loma Linda University School of Medicine, 11021 Campus Street, Alumni Hall 325, Loma Linda, CA 92352, USA.
Cell Immunol. 2008 Mar-Apr;252(1-2):27-56. doi: 10.1016/j.cellimm.2007.09.005. Epub 2008 Mar 4.
Optimal host defense against pathogens requires cross-talk between the nervous and immune systems. This paper reviews sympathetic-immune interaction, one major communication pathway, and its importance for health and disease. Sympathetic innervation of primary and secondary immune organs is described, as well as evidence for neurotransmission with cells of the immune system as targets. Most research thus far has focused on neural-immune modulation in secondary lymphoid organs, has revealed complex sympathetic modulation resulting in both potentiation and inhibition of immune functions. SNS-immune interaction may enhance immune readiness during disease- or injury-induced 'fight' responses. Research also indicate that dysregulation of the SNS can significantly affect the progression of immune-mediated diseases. However, a better understanding of neural-immune interactions is needed to develop strategies for treatment of immune-mediated diseases that are designed to return homeostasis and restore normal functioning neural-immune networks.
机体对病原体的最佳防御需要神经系统和免疫系统之间的相互作用。本文综述了交感神经 - 免疫相互作用这一主要的通讯途径及其对健康和疾病的重要性。文中描述了初级和次级免疫器官的交感神经支配情况，以及以免疫系统细胞为靶点进行神经传递的证据。迄今为止，大多数研究都集中在次级淋巴器官中的神经 - 免疫调节，揭示了复杂的交感神经调节，其结果是增强和抑制免疫功能。交感神经系统 - 免疫相互作用可能会在疾病或损伤诱导的“战斗”反应中增强免疫准备状态。研究还表明，交感神经系统的失调会显著影响免疫介导疾病的进展。然而，为了制定旨在恢复内环境稳定和恢复正常运作的神经 - 免疫网络的免疫介导疾病治疗策略，还需要更好地理解神经 - 免疫相互作用。
