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金鱼视前区多巴胺能神经元的存在。

Existence of dopaminergic neurons in the preoptic region of the goldfish.

作者信息

Kah O, Chambolle P, Thibault J, Geffard M

出版信息

Neurosci Lett. 1984 Aug 10;48(3):293-8. doi: 10.1016/0304-3940(84)90053-3.

DOI:10.1016/0304-3940(84)90053-3
PMID:6148727
Abstract

Three morphofunctional techniques for the detection of biogenic monoamines have been used in order to find evidence for the presence of dopaminergic neurons in the preoptic region of the goldfish. The formaldehyde-induced fluorescence technique and the immunohistochemical demonstration of tyrosine hydroxylase allowed the detection of cell bodies containing catecholamines in the ventral and lateral walls of the preoptic recess of the goldfish. Specific antibodies indicated that at least part of these perikarya contain dopamine. Evidence for the projection of these neurons to the pituitary are given. These results support the assumption that dopamine, originating from the preoptic region, may act as a gonadotrophin release-inhibiting factor in goldfish.

摘要

为了找到金鱼视前区存在多巴胺能神经元的证据,已使用三种形态功能技术来检测生物源性单胺。甲醛诱导荧光技术和酪氨酸羟化酶的免疫组织化学显示,可检测到金鱼视前隐窝腹侧壁和外侧壁中含有儿茶酚胺的细胞体。特异性抗体表明,这些核周体中至少有一部分含有多巴胺。给出了这些神经元向垂体投射的证据。这些结果支持这样的假设,即源自视前区的多巴胺可能作为金鱼促性腺激素释放抑制因子发挥作用。

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