Harmon J W, Norton J A, Collin M J, Krudy A G, Shawker T H, Doppman J L, d'Avis J, Jensen R T
Ann Surg. 1984 Oct;200(4):396-404. doi: 10.1097/00000658-198410000-00002.
There are two distinct problems in patients with Zollinger-Ellison Syndrome (ZES): peptic ulcer diathesis and malignant tumors. Antisecretory drugs have allowed us to control the ulcer symptoms and acid output in 45 patients with ZES. We report here the initial seven patients selected for surgical exploration with the goal of removing their gastrinomas. Prior to surgery, an extensive and rigorous protocol to localize the gastrinoma was carried out, including hypotonic duodenography, abdominal ultrasonography, selective arteriography, portal vein sampling for gastrin, and computerized tomography. With this protocol of radiographic localization, gastrinomas were found in two of the seven cases and the syndrome was "cured" in three of the seven patients. The results also demonstrate that preoperative localization is not a substitute for careful surgical exploration as tumors were found in two patients in whom localization failed.
佐林格-埃利森综合征（ZES）患者存在两个不同的问题：消化性溃疡素质和恶性肿瘤。抗分泌药物使我们能够控制45例ZES患者的溃疡症状和胃酸分泌。我们在此报告最初选择进行手术探查以切除胃泌素瘤的7例患者。手术前，实施了广泛而严格的胃泌素瘤定位方案，包括低张十二指肠造影、腹部超声检查、选择性动脉造影、门静脉取血检测胃泌素以及计算机断层扫描。通过这种影像学定位方案，7例患者中有2例发现了胃泌素瘤，7例患者中有3例“治愈”了该综合征。结果还表明，术前定位不能替代仔细的手术探查，因为在2例定位失败的患者中发现了肿瘤。
