二丁酰环磷酸腺苷、去甲肾上腺素和茶碱对大鼠脑突触体摄取45Ca的兴奋作用。

Excitatory effects of dibutyryl cyclic AMP, noradrenaline and theophylline on 45Ca uptake by synaptosomes from rat brain.

作者信息

Ribeiro J A, Sá-Almeida A M

出版信息

Arch Int Pharmacodyn Ther. 1984 Aug;270(2):215-31.

Abstract

The effects of dibutyryl cyclic AMP, noradrenaline and theophylline have been studied on the uptake of 45Ca by pinched-off presynaptic nerve terminals (synaptosomes) from rat brain. All three substances enhanced the high potassium (71 mM) stimulated 45Ca uptake. In the presence of normal potassium (5 mM) neither dibutyryl cyclic AMP nor theophylline changed significantly the uptake of 45Ca by synaptosomes, whilst noradrenaline increased the uptake of 45Ca and its effect was more evident than in the presence of high potassium. The results are discussed in relation to the role of cyclic AMP in the influx of calcium that triggers evoked release of transmitter.

摘要

已研究了二丁酰环磷酸腺苷（dibutyryl cyclic AMP）、去甲肾上腺素和茶碱对大鼠脑分离出的突触前神经末梢（突触体）摄取45Ca的影响。这三种物质均增强了高钾（71 mM）刺激的45Ca摄取。在正常钾浓度（5 mM）下，二丁酰环磷酸腺苷和茶碱均未显著改变突触体对45Ca的摄取，而去甲肾上腺素增加了45Ca的摄取，且其作用在高钾存在时比在正常钾浓度下更明显。结合环磷酸腺苷在触发递质诱发释放的钙内流中的作用对结果进行了讨论。