使用长效生长抑素类似物控制危及生命的回肠造口术腹泻。
Use of a long acting somatostatin analogue in controlling life threatening ileostomy diarrhoea.
作者信息
Williams N S, Cooper J C, Axon A T, King R F, Barker M
出版信息
Br Med J (Clin Res Ed). 1984 Oct 20;289(6451):1027-8. doi: 10.1136/bmj.289.6451.1027.
Abstract
A woman presented with persistent ileostomy diarrhoea unresponsive to conventional drug treatment and necessitating parenteral nutrition. Output was four to six litres of watery fluid per 24 hours while she was receiving oral nutrition and two to three litres when she was starved. Treatment with a long acting analogue of somatostatin (50 micrograms subcutaneously every 12 hours) reduced the ileostomy output to 2.0-2.5 litres/24 hours with an oral diet and the effluent became semiformed. Parenteral fluids could be stopped. Somatostatin may have a role in the treatment of secretory diarrhoea, but prospective controlled trials are necessary.
摘要
一名女性患者出现持续性回肠造口腹泻，对传统药物治疗无效，需要肠外营养。在接受口服营养时，每天的排出量为4至6升水样液体，饥饿时为2至3升。使用长效生长抑素类似物治疗（每12小时皮下注射50微克），采用口服饮食时，回肠造口排出量降至2.0 - 2.5升/24小时，流出物变为半成形。可以停止肠外补液。生长抑素可能在分泌性腹泻的治疗中发挥作用，但需要进行前瞻性对照试验。
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