Paiement J
J Pharm Pharmacol. 1984 Sep;36(9):614-5. doi: 10.1111/j.2042-7158.1984.tb04908.x.
The cmc of mixtures of chlorpromazine hydrochloride and polysorbate 80 was determined by pH titration. The values thus obtained coincided with those determined by the surface tension method. The mixtures studied could be divided into two groups according to the shape of their pH concentration curves. For mixtures containing less than 0.8 mole fraction chlorpromazine, the curves suggest that some interaction occurs in the premicellar concentration range. For mixtures containing more than 0.8 mole fraction chlorpromazine, the curves suggest that the micellar process occurs in more than one step.
通过pH滴定法测定了盐酸氯丙嗪与聚山梨酯80混合物的临界胶束浓度（cmc）。由此获得的值与通过表面张力法测定的值一致。根据pH浓度曲线的形状，所研究的混合物可分为两组。对于氯丙嗪摩尔分数小于0.8的混合物，曲线表明在胶束前浓度范围内发生了一些相互作用。对于氯丙嗪摩尔分数大于0.8的混合物，曲线表明胶束形成过程分不止一步发生。
