de Blasi A, Costantini C
J Pharm Pharmacol. 1984 Sep;36(9):630-2. doi: 10.1111/j.2042-7158.1984.tb04915.x.
Sulfinpyrazone increased the number of beta-adrenoceptors (+ 17-40%) on intact human lymphocytes at concentrations ranging from 10(-5) to 2 X 10(-4) M. It affected the Bmax (187 +/- 6 and 142 +/- 5 fmol mg-1 protein respectively with and without sulfinpyrazone, P less than 0.001) but did not influence KD (4.4 +/- 0.3 and 4.6 +/- 0.7 nM with and without the drug). This effect was observed on either washed or unwashed lymphocyte membrane preparations. These findings have several pharmacological and therapeutic implications.
磺吡酮在浓度为10(-5)至2×10(-4)M范围内可使完整人淋巴细胞上的β-肾上腺素能受体数量增加(+17 - 40%)。它影响最大结合容量（有和无磺吡酮时分别为187±6和142±5 fmol mg-1蛋白质，P<0.001），但不影响解离常数（有和无药物时分别为4.4±0.3和4.6±0.7 nM）。在洗涤过的或未洗涤过的淋巴细胞膜制剂上均观察到这种效应。这些发现具有若干药理学和治疗学意义。
